A number of diseases: AIDS, dengue, hepatitis, herpes, influenza, and polio, known to be caused by a viral infection to specific cells from humans. Infection by any virus is essentially an attempt to replicate the virus DNA / RNA her with the help of the host cell, the virus can not multiply the DNA / RNA of his own.
Therefore, DNA / RNA viruses can be considered as the most important component in the process of infection by viruses. The presence of obstacles or interference to doubling DNA / RNA virus could eventually lead to the failure of the assembly of new viruses in the host cell, so that the spread of infection by the virus can be prevented.
There are 4 nitrogen bases commonly found in DNA / RNA, namely: Adenine, Guanine, cytosine, and Thymine in DNA or RNA Uracyl on. Among the Nitrogen bases, there are nitrogen bases that are similar or have the same framework composition framework called purine (Adenine and Guanine).
Apparently in nature, there is an organic compound that also has a purine skeleton, the compound caffeine from coffee plants and compounds theobromine from cocoa. Because of the similarity structure Adenine and Guanine with fragments of the virus, these two compounds can compete with the virus in the multiplication .
When the competition was won by caffeine or theobromine, the doubling of the virus in the host cell to be inhibited , so that new viruses are assembled and fail failed to grow.
Antiviral efficacy of caffeine has been proven by Yamazaki and his friends in 1980 against herpes viruses, influenza, and polio. Then also made by Daniel and his friends against the HIV-1 virus.
Meanwhile, the coffee plant extracts antiviral efficacy has been demonstrated by Jianping and his colleagues in 2007 against hepatitis B virus and Arakawa et kawa 2009 against the influenza virus.
In its review, Arakawa and his kwan made the following statement, Caffeine can inhibit the multiplication of viruses are very different from mature structures, eg the protein envelope or not and how genome duplication and its translation.
When caffeine efficacious as a universal antiviral compounds, it can be hypothesized that theobromine arranged structurally similar to it may have equal efficacy.
Theobromine is the main secondary metabolites in plant seeds of cocoa (Theobroma cacao), which is the raw material for chocolate products and Perisa foods that are easily found in the Indonesian market.
It is worth noting that the activity of theobromine on the human central nervous system is lower than the activity of caffeine, theobromine so it tends to be safer than caffeine when consumed in large quantities.
In every 100 g of fresh beans, contained 2.4 g of the compound theobromine. Due to the availability of chocolate products in the Indonesian market, the outbreak of disease caused by any virus may be prevented by consuming chocolate drink.